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is urea natural or synthetic

Is urea natural or synthetic? “It’s a common question, and the answer is actually: both.

Urea, with the chemical formula CO(NH₂)₂, is a unique compound that is both a naturally occurring metabolite in living organisms and an important chemical synthesized through large-scale industrial processes. Understanding the two distinct sources of urea is crucial for recognizing its widespread applications in biology, agriculture, and industry.

Natural urea: produced by living organisms

In living organisms, urea is a key nitrogen-containing metabolic waste product produced by animals (including humans), plants, and certain microorganisms through biological metabolic processes. It is a byproduct of nitrogen metabolism and is crucial for the elimination of excess nitrogen in living organisms.  

The generation mechanism of natural urea

Animal metabolic processes: In mammals, birds, and crawling objects, excess nitrogen produced by protein breakdown in food is converted into urea in the liver through the urea cycle (also known as the ornithine cycle). This process combines toxic metabolic waste ammonia with carbon dioxide to form non-toxic urea, which is then excreted from the body through urine. For example, the urea content in human urine ranges from 2% to 5%, which is one of the highest sources of natural urea concentration.  

Plant and Microbial Production: Microorganisms in plants and soil (such as bacteria and fungi) also produce small amounts of natural urea. Plants can synthesize urea through amino acids or absorb urea from soil (from animal excrement or organic matter decomposition); Microorganisms will decompose organic matter (such as dead branches and feces) and release urea as part of the nitrogen cycle.  

The core characteristics of natural urea

Natural impurities: Natural urea never exists in pure form and is always mixed with other substances. Urine contains water, salt, and organic compounds, while urea in soil coexists with minerals and microorganisms.  

Low concentration: Even in urine (the most concentrated source of natural urea), urea accounts for only a small proportion, far lower than synthetic urea (purity often reaches 99%).  

Ecosystem role: Natural urea plays a crucial role in the nitrogen cycle. When it enters the environment through excretion or decomposition, it decomposes into ammonia and nitrogen elements that plants can absorb and utilize, thereby forming an ecological loop between animals, plants, and soil.  

Therefore, from a biological perspective, urea is completely natural and an indispensable part of life activities.

Synthetic urea: for industrial production and manufacturing

Synthetic urea is produced through chemical reactions in factories, using inorganic compounds as raw materials. The urea we come into contact with in our daily lives (such as fertilizers, AdBlue diesel exhaust treatment solution, and urea in skincare products) is mostly synthetic urea.  

Production process of synthetic urea

The process of modern industrial synthesis of urea began in the early 20th century, mainly relying on two abundant raw materials:

Industrial production: Currently, the industrial production of urea is primarily carried out through the Bosch-Meiser Urea Process. This process involves the reaction of ammonia (NH₃) and carbon dioxide (CO₂) under high temperatures and pressures, first producing ammonium formate, and then dehydrating it to produce urea.

2NH₃ + CO₂ → H₂NCOONH₄
H₂NCOONH₄ → (NH₂)₂CO + H₂O

This synthesis method is highly efficient and relatively low-cost, enabling large-scale production of urea to meet the global demand for fertilizers and other industrial products. The generated urea will be purified (to remove moisture and impurities), processed into particles, powders, or solutions, and ultimately used in industrial settings.  

Core characteristics of synthetic urea

High purity: The purity of industrial synthetic urea can reach 95 -99%, with an extremely low impurity content, which is crucial for pharmaceutical, AdBlue, and other scenarios, as impurities may cause equipment damage or reaction failure.  

Controllable concentration: Manufacturers can adjust the concentration of synthetic urea to meet their specific needs. For example, the urea concentration in AdBlue must be strictly controlled at 32.5% (in accordance with ISO 22241 standards), whereas the urea nitrogen content in fertilizers is typically 46%.  

Large-scale production: Synthetic urea can achieve an annual output of millions of tons, meeting the huge demand in the global agricultural, industrial, and medical fields.

How choose "natural" and "synthetic" urea?  

The choice between natural urea and synthetic urea depends entirely on the specific application scenario:

Agricultural field

Synthetic urea is the preferred fertilizer. Its high purity and concentration of nitrogen can provide stable and efficient nutrients for plants, which is crucial for feeding the growing global population.  

Natural urea: found in organic fertilizers such as feces and compost. Due to the slow release of nitrogen when microorganisms decompose organic matter, natural urea is more suitable for organic agriculture; however, its efficiency is lower than that of synthetic urea, making it difficult to meet the needs of large-scale crop cultivation.  

Industrial sector

Synthetic urea: It is the core raw material for manufacturing AdBlue (reducing diesel vehicle emissions), plastics (such as urea formaldehyde resin), and textiles. Impurities in natural urea can damage vehicle SCR systems or disrupt chemical reactions; therefore, high-purity synthetic urea must be used in industrial scenarios.  

Medical field

Synthetic urea: used in skincare products (moisturizing, exfoliating) and pharmaceuticals (diuretics, kidney disease treatment drugs). Natural urea (such as urea in urine) does not meet hygiene standards and has low purity, making it unsuitable for medical use. Synthetic urea is the only safe option.

Environmental impact

Natural urea is part of the ecological loop, where animal excrement releases urea, which nourishes plants, and plants in turn provide food for animals, all with an extremely low carbon footprint (no industrial production required).  

Synthetic urea: Traditional production relies on the Haber Bosch process (which uses fossil fuels as energy and generates carbon dioxide emissions). However, the development of “green urea” technology (using renewable energy to produce ammonia) is gradually reducing its environmental impact.  

conclusion

Overall, urea is both natural and synthetic, but each form has its own distinct uses. Natural urea is a biological byproduct that maintains ecosystems, while synthetic urea is a key industrial product that supports agriculture, emissions reduction, and healthcare. Understanding the differences between the two can help us choose the appropriate type based on our needs: organic agriculture and ecological cycling can rely on natural urea, while high-purity and large-scale application scenarios require synthetic urea.

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